Treatment of Aphthous Stomatitis

Apremilast for treatment of recalcitrant aphthous stomatitis

IL: interleukin RAS: recurrent aphthous stomatitis OBSERVATION Recurrent aphthous stomatitis (RAS) is a common cause of recurrent oral ulcers, which often leads to significant impairment of a patient’s quality of life. The underlying pathogenic mechanism remains unclear, and no treatment modality is uniformly effective. In this report, we describe the use of apremilast, an oral phosphodiesteras...

Efficacy of alum for treatment of recurrent aphthous stomatitis

Background: Recurrent aphthous stomatitis (RAS) is the most common painful ulcers of oral mucosal which can cause many sufferings. Treatment of RAS often includes administration of corticosteroids, analgesics and regulators of the immune system. However, considering the side effects of these medications, even their topical application must be done with caution. Alum is used in traditional medic...

Recurrent Aphthous Stomatitis

Recurrent aphthous stomatitis (RAS) is a common disorder affecting 5% to 66% of examined adult patient groups. There may be a female predominance in some adult and child patient groups.1–4 The ulceration usually commences in the second decade,5 although 40% of selected groups of children can have a history of RAS, ulceration beginning before 5 years of age, the frequency of affected patients ri...

Treatment of severe, recalcitrant, major aphthous stomatitis with adalimumab.

We describe an 18-year-old man with a 7-year history of severe major aphthous stomatitis refractory to multiple standard therapies who responded completely to therapy with adalimumab, a fully humanized monoclonal antibody against tumor necrosis factor alpha (TNF-alpha).

Recurrent aphthous stomatitis.